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Clinical trial exploration

Clinical trials.
A clearer place to start.

Finding studies is only the beginning. Understanding which ones deserve a closer look is harder.

Share your clinical history with Nuncius and ask the questions that matter to you. Explore relevant studies, understand their requirements, and prepare your next conversation with your care team.

Ask about clinical trials See an example

Start with what you know. You don’t need to understand every medical term.

ClinicalTrials.gov sourcesYour context, in conversationQuestions for your care team

From searching to understanding

From a question to something you can use.

You shouldn’t have to become a clinical-trials expert to understand your options.

NUNCIUS HealthReal registry records. An illustrated conversation.
Source-based illustration, not a live search or a saved Nuncius answer. Registry snapshot checked . These examples are not a complete search or an eligibility assessment.
Example question

“I have non-small cell lung cancer with an MTAP deletion. Are there clinical trials I could discuss with my oncologist?”

A useful starting point is to examine the study’s requirements—not just whether it mentions MTAP. Here are two real records that illustrate what to look at.

Relevant to the questionPhase 1 / 2

BAY 3713372

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

Investigates BAY 3713372, alone and in combination with other treatments, in people with MTAP-deleted tumors.

Why look closer
The registry describes dose-expansion cohorts specifically for MTAP-deleted non-small cell lung cancer.
Needs clarification
The listed criteria include homozygous MTAP deletion confirmed by molecular testing and an ECOG performance status of 0 or 1.
A question for your care team

Does my report confirm homozygous MTAP deletion, and which study cohort would need to review my case?

Registry status at snapshot: RecruitingRegistry last updated:
NCT06914128 · Read the original record (opens in a new tab)
Relevant to the questionPhase 1 / 2

TNG462

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

Investigates the oral PRMT5 inhibitor TNG462 in people with MTAP-deleted solid tumors.

Why look closer
This broader solid-tumor study includes MTAP-related criteria; the study team would need to check the applicable tumor cohort.
Needs clarification
The listed criteria require locally advanced, metastatic, and/or unresectable disease, prior standard therapy as available, and qualifying MTAP testing.
A question for your care team

Does my disease setting meet the requirements, and what previous treatments and test results would the study team need?

Registry status at snapshot: RecruitingRegistry last updated:
NCT05732831 · Read the original record (opens in a new tab)

Selected requirements only. Read the full inclusion and exclusion criteria. Recruitment, cohort availability, and eligibility must be checked with the study team.

Illustrated follow-up“My cancer is early-stage. Does that change things?”
Potential mismatch

Yes—the disease setting matters. The TNG462 record shown above requires locally advanced, metastatic, and/or unresectable disease. An early-stage diagnosis alone does not establish that requirement. The biomarker connection is not enough to call this study a fit.

A useful next question: “What is my exact stage, is my cancer resectable, and which studies investigate that setting?” The other study’s cohort requirements also need independent review.

More than a list of studies

Less searching through jargon. More understanding.

Ask in your own words.

Describe your cancer, a molecular finding, or a treatment you want to investigate. You don’t need to construct a registry search yourself.

Understand why a study may matter.

Explore how the study’s disease setting, biomarkers, and treatment requirements relate to the information you provided.

See what still needs checking.

Identify unclear requirements, potential conflicts, and questions for your oncologist or the study team.

Your situation matters

A study is about more than a biomarker.

Share what you know. Ask follow-up questions as the picture becomes clearer.

You can provide these details in the conversation. You do not need a complete profile, and you do not need to include identifying information.

  1. 01

    Your cancer

    Cancer type and stage, if you know them.

  2. 02

    Your molecular findings

    Biomarkers or alterations described in your report.

  3. 03

    Your treatment history

    Treatments you have already received or want to investigate.

  4. 04

    Your location

    Where you live and any travel constraints.

  5. 05

    Your questions

    A particular study, treatment, or requirement you want to understand.

Keep the conversation going

You don’t need the perfect first question.

Start with your biggest concern. Then explore the details that matter to you.

  • “Which studies require previous treatment?”
  • “What does phase 1 mean?”
  • “Which requirements should I ask my oncologist about?”
  • “Are any locations listed in California?”

Example questions, not interactive prompts. Ask your own question after signing in.

Evidence you can examine

Understand the opportunity—and the limits.

Trace it to the registry.

Nuncius uses study information from ClinicalTrials.gov and explains its relevance to the details you share. Follow the original records to examine the requirements and study information.

Keep the full picture in view.

Registry information can be incomplete or outdated. A shortlist is not exhaustive, and overall recruitment status does not guarantee an opening at a particular location.

Bring your care team with you.

Your care team and the study team determine whether participation is appropriate and whether you meet the requirements. Nuncius does not confirm eligibility or replace that assessment.

Practical questions

A few things you might be wondering.

Can I search without knowing my biomarkers?

Yes. Start with the cancer type and information you know. Molecular findings can help focus some searches, but you do not need a complete profile to begin. Nuncius can explain what additional information may help.

Can a caregiver ask on someone’s behalf?

Yes. You can ask questions using relevant clinical details shared with the patient’s permission. You do not need to include names, contact details, or other identifying information in your question.

Can I ask about early-stage cancer?

Yes. Include the stage and whether surgery or other treatment has taken place, if you know. Different studies investigate different disease settings; a biomarker alone does not establish relevance.

Can I explore studies in a particular location?

Yes. Name a city, state, or country in your question. Nuncius can explore listed study locations, but does not guarantee a nearby opening, travel feasibility, or availability at a particular site.

Does a relevant study mean I qualify?

No. Study requirements can involve treatment history, test results, overall health, and other factors. Nuncius can help you understand selected criteria, but your care team and the study team must assess eligibility and suitability.

What if Nuncius does not find a close match?

That does not mean no trials exist. A search may return studies that address only part of your question, with differences or uncertainties explained. You can refine the question, share more context, and discuss other search options with your care team.

Does Nuncius enroll me or contact the study team?

No. Nuncius helps you explore and understand information. It does not enroll patients, reserve places, or contact study teams on your behalf. Original registry records provide the place to check study contacts and complete requirements.

Is trial exploration included in the Free plan?

Yes. Clinical-trial questions use the same question allowance as other Ask Nuncius questions. The Free plan includes 10 questions per calendar month; follow-up questions also use that allowance. Pro includes unlimited questions, subject to standard usage safeguards.

Your next conversation

Bring a clearer set of questions to your next appointment.

Explore the studies, understand what needs checking, and discuss your next steps with your care team.

Ask Nuncius about clinical trials

Create an account to ask. Free includes 10 questions per calendar month.